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Latest News

Are New, Popular Weight-Loss Drugs Safe for People With HIV?

June 12, 2024

The safety of new weight loss drugs for people with HIV is being investigated, focusing on potential interactions with antiretroviral therapy and ensuring they do not compromise HIV treatment efficacy or overall health

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Switching from TAF to TDF leads to weight loss

April 23, 2024

Switching from tenofovir alafenamide (TAF) to tenofovir disoproxil fumarate (TDF) in HIV treatment results in modest weight loss and improvements in cholesterol and triglyceride levels.

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Weight gain on HIV treatment: more than a 'return to health' phenomenon?

March 28, 2024

Weight gain associated with HIV treatments, particularly those using integrase inhibitors, is more complex than previously thought, prompting further research into drug-specific effects.

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Famous weight loss drug may help people with HIV get healthier, MUSC researcher says

March 15, 2024

The weight loss drug semaglutide may improve health outcomes for people with HIV by reducing weight and addressing obesity-related health issues, according to MUSC researchers.

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Switch to an integrase inhibitor leads to greater weight during and after the menopause

March 11, 2024

Switching to an integrase inhibitor during menopause is linked to significant weight gain in women with HIV, particularly affecting visceral fat and body mass index.

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HIV studies with semaglutide: significant benefits but limited access for treatment and research

March 10, 2024

Studies presented at CROI 2024 show significant benefits of semaglutide for weight loss and metabolic health in people with HIV, though access to the drug remains limited due to high demand and cost.

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Greater weight gain in pregnancy reduces the risk of adverse outcomes for women with HIV

February 27, 2024

More significant weight gain during pregnancy in women with HIV, especially with dolutegravir-based treatment, is associated with reduced risk of adverse birth outcomes such as premature birth and stillbirth.

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Study explores weight gain with HIV treatment

February 6, 2024

A Kaiser Permanente study found that people with HIV starting antiretroviral treatment (ART) experienced greater weight gain over two years compared to those without HIV, with weight gain varying by ART medication class and typically stabilizing after the initial period.

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Unhealthy Weight Gain Potential Side Effect of Antiretroviral Therapy

January 31, 2024

Recent antiretroviral therapy (ART) has been linked to unhealthy weight gain, particularly affecting women and black populations, posing new clinical challenges in managing obesity among people living with HIV.

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Safely Losing Weight on HIV Treatment

December 7, 2023

Managing weight with HIV treatment is crucial, as treatments can lead to both weight loss and gain. Balancing a healthy diet and regular exercise can help maintain optimal weight and improve overall health.

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Weight Gain While Treating HIV: Why It Happens

December 7, 2023

Weight gain is a common issue for people on HIV treatment, particularly with antiretroviral therapy, and managing this side effect is crucial for overall health and treatment efficacy.

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New weight-loss drugs appear safe and effective for people living with HIV

November 16, 2023

New weight-loss drugs like semaglutide and tirzepatide appear safe and effective for people living with HIV, offering significant benefits for managing weight and related health complications, although more research is needed.

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Do Weight-Loss Drugs Work for People With HIV?

November 13, 2023

Studies indicate that weight-loss drugs like semaglutide and tirzepatide are safe and effective for people living with HIV, offering significant benefits for weight management and reducing metabolic complications.

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Weight-Loss Drug Effective in People With HIV, But May Worsen Muscle Loss and Lipoatrophy

October 17, 2023

Semaglutide, a GLP-1 agonist, has shown promise in managing weight, muscle mass, and lipoatrophy in people living with HIV, as presented at IDWeek 2023, highlighting its potential benefits in this population.

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Greater weight gain in first year of HIV treatment raises risks of diabetes, metabolic syndrome and precursors of heart disease

October 2, 2023

Greater weight gain in the first year of HIV treatment increases the risk of diabetes, metabolic syndrome, and precursors of heart disease, with variations in risk based on race and sex.

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Switches away from integrase inhibitors do not reverse weight gain, studies find

July 27, 2023

Switching away from integrase inhibitors does not reverse weight gain in people with HIV, as studies have shown continued weight gain with alternative regimens.

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More Studies Explore Weight Gain

March 29, 2023

Studies indicate that weight gain linked to HIV treatment is influenced by factors like changes in fat metabolism and the gut microbiome, with newer drugs such as TAF and integrase inhibitors often causing more weight gain.

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INSTI Use Beyond Two Years Not Associated With Greater Weight Gain in Global REPRIEVE Study

March 16, 2023

People with HIV starting integrase strand transfer inhibitors (INSTIs) may experience weight gain, but a two-year study shows a subsequent stabilization in weight, providing a reprieve from initial increases.

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Weight gain on HIV treatment greater in people who start treatment with advanced HIV

March 9, 2023

People with advanced HIV who start antiretroviral treatment experience greater weight gain compared to those who begin treatment with higher CD4 counts, with integrase inhibitors and tenofovir alafenamide being significant contributors.

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French study finds strikingly less weight gain when HIV treatment is begun early

March 7, 2023

A French study found that initiating HIV treatment early significantly reduces the extent of weight gain compared to starting treatment later, suggesting early treatment initiation can mitigate excessive weight gain associated with antiretroviral therapy.

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Weight loss after treatment switch more likely for those with higher body mass

February 28, 2023

Weight loss after switching from tenofovir alafenamide (TAF) and an integrase inhibitor is more likely in individuals with higher body mass index (BMI), especially those classified as clinically obese.

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Dutch study explores issue of weight gain with changes in HIV treatment

August 16, 2022

A Dutch study found that switching to HIV treatments including tenofovir alafenamide (TAF) and integrase inhibitors significantly increased the risk of weight gain, especially among women, younger individuals, and those who had lost weight prior to the switch.

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Weight Gain and HIV Treatment: A Complex Relationship

November 19, 2021

Weight gain linked to antiretroviral therapy is a significant concern for people with HIV, with certain treatments causing more pronounced increases in body weight, necessitating careful management and monitoring of treatment regimens to mitigate these effects.

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Cabenuva Works Well Regardless of Body Weight

November 3, 2021

Cabenuva, a long-acting injectable HIV treatment, effectively suppresses HIV regardless of body weight, though longer needles may be needed for individuals with obesity to ensure proper administration.

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People with HIV gain weight faster than HIV-negative people

July 4, 2020

People with HIV on antiretroviral treatment gain weight faster than HIV-negative individuals, with the rate of weight gain being three times higher and resulting in a higher body mass over a 12-year follow-up period.

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Rapid weight gain after switching to TAF, regardless of other HIV drugs taken

July 4, 2020

Switching to tenofovir alafenamide (TAF) from tenofovir disoproxil fumarate (TDF) results in rapid weight gain, regardless of other HIV drugs taken.

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Popular anti-HIV drugs result in ‘10 years of weight gain in 2 years' for some women

August 7, 2019

Popular anti-HIV drugs, particularly integrase inhibitors, have been linked to significant weight gain in some women, equivalent to what would typically be expected over a decade, occurring within just two years of treatment.

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HIV-Related Immune Activation May Predict Weight Gain and Exacerbate Complications, Especially in Women

March 7, 2019

HIV-related immune activation may predict weight gain and worsen health complications, particularly in women, even with effective antiretroviral therapy.

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